| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SERBP1 |
| Gene ID: |
26135 |
| Uniprot ID: |
SERB1_HUMAN |
| Immunogen Region: |
1-114 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-114 of human SERBP1 (NP_001018078.1). |
| Immunogen Sequence: |
MPGHLQEGFGCVVTNRFDQL FDDESDPFEVLKAAENKKKE AGGGGVGGPGAKSAAQAAAQ TNSNAAGKQLRKESQKDRKN PLPPSVGVVDKKEETQPPVA LKKEGIRRVGRRPD |
| Tissue Specificity | Expressed at high level in the heart, skeletal muscle and kidney, and at low levels in placenta, liver and brain. |
| Post Translational Modifications | Phosphorylation by MTOR inhibits SERBP1 and relieves ribosome hibernation. |
| Function | Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation. Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state. May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. Seems to play a role in PML-nuclear bodies formation. |
| Protein Name | Serpine1 Mrna-Binding Protein 1Pai1 Rna-Binding Protein 1Pai-Rbp1Plasminogen Activator Inhibitor 1 Rna-Binding Protein |
| Cellular Localisation | CytoplasmNucleusPerinuclear Region |
| Alternative Antibody Names | Anti-Serpine1 Mrna-Binding Protein 1 antibodyAnti-Pai1 Rna-Binding Protein 1 antibodyAnti-Pai-Rbp1 antibodyAnti-Plasminogen Activator Inhibitor 1 Rna-Binding Protein antibodyAnti-SERBP1 antibodyAnti-PAIRBP1 antibodyAnti-CGI-55 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
