| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NRARP (1-114) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NRARP |
| Gene ID: |
441478 |
| Uniprot ID: |
NRARP_HUMAN |
| Immunogen Region: |
1-114 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-114 of human NRARP (NP_001004354.1). |
| Immunogen Sequence: |
MSQAELSTCSAPQTQRIFQE AVRKGNTQELQSLLQNMTNC EFNVNSFGPEGQTALHQSVI DGNLELVKLLVKFGADIRLA NRDGWSALHIAAFGGHQDIV LYLITKAKYAASGR |
| Function | Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal. Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis. During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and down-regulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain. |
| Protein Name | Notch-Regulated Ankyrin Repeat-Containing Protein |
| Alternative Antibody Names | Anti-Notch-Regulated Ankyrin Repeat-Containing Protein antibodyAnti-NRARP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Immunoprecipitation of DBI in 300 µg extracts from HeLa cells using 3 µg [KO Validated] DBI Rabbit polyclonal antibody (STJ119997). Western blot analysis was performed using [KO Validated] DBI Rabbit polyclonal antibody (STJ119997) at 1:1000 dilution.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/98782/382831/STJ119997_1__34510.1713151335.jpg?c=1 "Immunoprecipitation of DBI in 300 µg extracts from HeLa cells using 3 µg [KO Validated] DBI Rabbit polyclonal antibody (STJ119997). Western blot analysis was performed using [KO Validated] DBI Rabbit polyclonal antibody (STJ119997) at 1:1000 dilution.")
