| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SEC11A |
| Gene ID: | 23478 |
| Uniprot ID: | SC11A_HUMAN |
| Immunogen Region: | 37-145 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 37-145 of human SEC11A (NP_055115.1). |
| Immunogen Sequence: | KGLMVITGSESPIVVVLSGS MEPAFHRGDLLFLTNRVEDP IRVGEIVVFRIEGREIPIVH RVLKIHEKQNGHIKFLTKGD NNAVDDRGLYKQGQHWLEKK DVVGRARGF |
| Function | Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids. |
| Protein Name | Signal Peptidase Complex Catalytic Subunit Sec11aEndopeptidase Sp18Microsomal Signal Peptidase 18 Kda SubunitSpase 18 Kda SubunitSec11 Homolog ASec11-Like Protein 1Spc18 |
| Database Links | Reactome: R-HSA-1799339Reactome: R-HSA-381771Reactome: R-HSA-400511Reactome: R-HSA-422085Reactome: R-HSA-9828806 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Signal Peptidase Complex Catalytic Subunit Sec11a antibodyAnti-Endopeptidase Sp18 antibodyAnti-Microsomal Signal Peptidase 18 Kda Subunit antibodyAnti-Spase 18 Kda Subunit antibodyAnti-Sec11 Homolog A antibodyAnti-Sec11-Like Protein 1 antibodyAnti-Spc18 antibodyAnti-SEC11A antibodyAnti-SEC11L1 antibodyAnti-SPC18 antibodyAnti-SPCS4A antibody |
Information sourced from Uniprot.org