| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SCTR (151-461) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SCTR |
| Gene ID: |
6344 |
| Uniprot ID: |
SCTR_HUMAN |
| Immunogen Region: |
151-461 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 151-461 of human SCTR (P47872). |
| Immunogen Sequence: |
SSSLVMLLVALGILCAFRRL HCTRNYIHMHLFVSFILRAL SNFIKDAVLFSSDDVTYCDA HRAGCKLVMVLFQYCIMANY SWLLVEGLYLHTLLAISFFS ERKYLQGFVAFGWGSPAIFV ALWAIARHFLEDVGCWDINA NASIWWIIRGPVILSILINF ILFINILRILMRKLRTQETR GNEVSHYKRLARSTLLLIPL FGIHYIVFAFSPEDAMEIQL FFELALGSFQGLVVAVLYC |
| Post Translational Modifications | Phosphorylated on Ser and Thr residues at the cytoplasmic C-terminus by G protein-coupled receptor kinases (GRKs). |
| Function | Receptor for secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas. In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation by regulating renal water reabsorption. Also plays a role in the central nervous system: required for synaptic plasticity. |
| Protein Name | Secretin ReceptorSct-R |
| Database Links | Reactome: R-HSA-418555Reactome: R-HSA-420092 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Secretin Receptor antibodyAnti-Sct-R antibodyAnti-SCTR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
