Anti-S100A1 antibody (10-59 aa) (STJ95562)

Name: Anti-S100A1 antibody (10-59 aa) (STJ95562)
SKU: STJ95562
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

ImmunogenThe antiserum was produced against synthesized peptide derived from the human S100 A1 at the amino acid range 10-59

STJ95562

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Short Description	Rabbit polyclonal anti-Protein S100-A1 (10-59 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC/IF/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	1 mg/mL
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Dilution Range	WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:20000
Formulation	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	S100A1
Gene ID	6271
Uniprot ID	S10A1_HUMAN
Immunogen	The antiserum was produced against synthesized peptide derived from the human S100 A1 at the amino acid range 10-59
Immunogen Region	10-59 aa
Specificity	S-100 Alpha Polyclonal Antibody detects endogenous levels of S-100 Alpha protein.

Post Translational Modifications	Glutathionylated.glutathionylation increases affinity to calcium about 10-fold.
Function	Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes. These changes allow interactions with specific target proteins and modulate their activity. Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase. Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole.
Protein Name	Protein S100-A1 S-100 Protein Alpha Chain S-100 Protein Subunit Alpha S100 Calcium-Binding Protein A1
Database Links	Reactome: R-HSA-1236974 Reactome: R-HSA-166058 Reactome: R-HSA-5602498 Reactome: R-HSA-5603041 Reactome: R-HSA-5686938
Cellular Localisation	Cytoplasm Sarcoplasmic Reticulum Mitochondrion
Alternative Antibody Names	Anti-Protein S100-A1 antibody Anti-S-100 Protein Alpha Chain antibody Anti-S-100 Protein Subunit Alpha antibody Anti-S100 Calcium-Binding Protein A1 antibody Anti-S100A1 antibody Anti-S100A antibody

Information sourced from Uniprot.org