Anti-RHBDD1 antibody (206-315) (STJ116576)

SKU:
STJ116576

Shipping:
Free Shipping
Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-RHBDD1 (206-315) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RHBDD1
Gene ID: 84236
Uniprot ID: RHBL4_HUMAN
Immunogen Region: 206-315
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 206-315 of human RHBDD1 (NP_115652.2).
Immunogen Sequence: TQGPLKKIMEACAGGFSSSV GYPGRQYYFNSSGSSGYQDY YPHGRPDHYEEAPRNYDTYT AGLSEEEQLERALQASLWDR GNTRNSPPPYGFHLSPEEMR RQRLHRFDSQ
Tissue Specificity Expressed strongly in testis.
Function Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Functions in BIK, MPZ, PKD1, PTCRA, RHO, STEAP3 and TRAC processing. Involved in the regulation of exosomal secretion.inhibits the TSAP6-mediated secretion pathway. Involved in the regulation of apoptosis.modulates BIK-mediated apoptotic activity. Also plays a role in the regulation of spermatogenesis.inhibits apoptotic activity in spermatogonia.
Protein Name Rhomboid-Related Protein 4
Rrp4
Rhomboid Domain-Containing Protein 1
Rhomboid-Like Protein 4
Cellular Localisation Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Mitochondrion Membrane
Alternative Antibody Names Anti-Rhomboid-Related Protein 4 antibody
Anti-Rrp4 antibody
Anti-Rhomboid Domain-Containing Protein 1 antibody
Anti-Rhomboid-Like Protein 4 antibody
Anti-RHBDD1 antibody
Anti-RHBDL4 antibody
Anti-HSD-50 antibody
Anti-HSD50 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance