| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RGS9 (230-350) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RGS9 |
| Gene ID: |
8787 |
| Uniprot ID: |
RGS9_HUMAN |
| Immunogen Region: |
230-350 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 230-350 of human RGS9 (NP_003826.2). |
| Immunogen Sequence: |
MYYQQALMRSTVKSSVSLGG IVKYSEQFSSNDAIMSGCLP SNPWITDDTQFWDLNAKLVE IPTKMRVERWAFNFSELIRD PKGRQSFQYFLKKEFSGENL GFWEACEDLKYGDQSKVKEK A |
| Tissue Specificity | Highly expressed in the caudate and putamen, lower levels found in the hypothalamus and nucleus accumbens and very low levels in cerebellum. Not expressed in globus pallidus or cingulate cortex. Isoform 2 is expressed predominantly in pineal gland and retina. Isoform 3 is expressed in retina (abundant in photoreceptors). |
| Post Translational Modifications | Retinal isoform 3 is light-dependent phosphorylated at 'Ser-478'. Phosphorylation is decreased by light exposition. |
| Function | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction.key element in the recovery phase of visual transduction. |
| Protein Name | Regulator Of G-Protein Signaling 9Rgs9 |
| Database Links | Reactome: R-HSA-2514859 O75916-3Reactome: R-HSA-418594Reactome: R-HSA-6814122 |
| Cellular Localisation | Isoform 3: MembranePeripheral Membrane ProteinIsoform 3 Is Targeted To The Membrane Via Its Interaction With Rgs9bp |
| Alternative Antibody Names | Anti-Regulator Of G-Protein Signaling 9 antibodyAnti-Rgs9 antibodyAnti-RGS9 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and Prion Protein knockout (KO) HeLa cells, using [KO Validated] Prion Protein Rabbit polyclonal antibody (STJ11100031) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89103/357560/STJ11100031_1__14868.1713121685.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and Prion Protein knockout (KO) HeLa cells, using [KO Validated] Prion Protein Rabbit polyclonal antibody (STJ11100031) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.")
