| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RGS4 (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RGS4 |
| Gene ID: |
5999 |
| Uniprot ID: |
RGS4_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human RGS4 (NP_005604.1). |
| Immunogen Sequence: |
MCKGLAGLPASCLRSAKDMK HRLGFLLQKSDSCEHNSSHN KKDKVVICQRVSQEEVKKWA ESLENLISHECGLAAFKAFL KSEYSEENIDFWISCEEYKK |
| Tissue Specificity | Expressed in brain and heart. Expressed in brain at protein level. Expressed in prefontal and visual cortex. Isoform 4 and isoform 5 are expressed ubiquitously. Isoform 1, isoform 2 and isoform 3 are not expressed in the cerebellum. |
| Post Translational Modifications | Palmitoylated on Cys-2 and/or Cys-12. Phosphorylated by cyclic GMP-dependent protein kinase. |
| Function | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. |
| Protein Name | Regulator Of G-Protein Signaling 4Rgp4Rgs4 |
| Database Links | Reactome: R-HSA-416476Reactome: R-HSA-418594Reactome: R-HSA-418597 |
| Alternative Antibody Names | Anti-Regulator Of G-Protein Signaling 4 antibodyAnti-Rgp4 antibodyAnti-Rgs4 antibodyAnti-RGS4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
