• Western blot analysis of extracts of U-251MG cells, using RGS3 antibody (STJ28802) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 5min.

Anti-RGS3 antibody (1-270) (STJ28802)

SKU:
STJ28802

£169.50 - £449.50
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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-RGS3 (1-270) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RGS3
Gene ID: 5998
Uniprot ID: RGS3_HUMAN
Immunogen Region: 1-270
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human RGS3 (NP_570613.2).
Immunogen Sequence: MNRFNGLCKVCSERRYRQIT IPRGKDGFGFTICCDSPVRV QAVDSGGPAERAGLQQLDTV LQLNERPVEHWKCVELAHEI RSCPSEIILLVWRMVPQVKP GPDGGVLRRASCKSTHDLQS PPNKREKNCTHGVQARPEQR HSCHLVCDSSDGLLLGGWER YTEVAKRGGQHTLPALSRAT APTDPNYIILAPLNPGSQLL RPVYQEDTIPEESGSPSKGK SYTGLGKKSRLMKTVQTMK
Post Translational Modifications Phosphorylated by cyclic GMP-dependent protein kinase. ISGylated.
Function Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.
Protein Name Regulator Of G-Protein Signaling 3
Rgp3
Rgs3
Database Links Reactome: R-HSA-416476
Reactome: R-HSA-418594
Cellular Localisation Cytoplasm
Nucleus
Cell Membrane
Peripheral Membrane Protein
Long Isoforms Are Cytoplasmic And Associated With The Plasma Membrane
Short Isoforms Are Nuclear
Alternative Antibody Names Anti-Regulator Of G-Protein Signaling 3 antibody
Anti-Rgp3 antibody
Anti-Rgs3 antibody
Anti-RGS3 antibody

Information sourced from Uniprot.org

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