Anti-Recombinant-WTAP antibody [RM2F84] (STJA0025553)

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STJA0025553
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Host: Rabbit
Applications: IHC/IP/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Pre-Mrna-Splicing Regulator Wtap is suitable for use in Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM2F84
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: IHC: 1:50-1:100, IP: 1:20, WB: 1:500-1:1000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: WTAP
Gene ID: 9589
Uniprot ID: FL2D_HUMAN
Function Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Required for accumulation of METTL3 and METTL14 to nuclear speckle. Acts as a mRNA splicing regulator. Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes.
Protein Name Pre-Mrna-Splicing Regulator Wtap
Female-Lethal(2d Homolog
Hfl(2d
Wt1-Associated Protein
Wilms Tumor 1-Associating Protein
Database Links Reactome: R-HSA-72203
Cellular Localisation Nucleus Speckle
Nucleus
Nucleoplasm
Cytoplasm
Mainly Nuclear With Some Fraction Located In The Cytoplasm
Zc3h13 Is Required To Anchor Component Of The Macom Subcomplex
Such As Virma
In The Nucleus
Alternative Antibody Names Anti-Pre-Mrna-Splicing Regulator Wtap antibody
Anti-Female-Lethal(2d Homolog antibody
Anti-Hfl(2d antibody
Anti-Wt1-Associated Protein antibody
Anti-Wilms Tumor 1-Associating Protein antibody
Anti-WTAP antibody
Anti-KIAA0105 antibody

Information sourced from Uniprot.org

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