| Function | Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. |
| Protein Name | Squalene SynthaseSqsSsFpp -Fpp FarnesyltransferaseFarnesyl-Diphosphate FarnesyltransferaseFarnesyl-Diphosphate Farnesyltransferase 1 |
| Database Links | Reactome: R-HSA-191273Reactome: R-HSA-1989781Reactome: R-HSA-2426168 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Squalene Synthase antibodyAnti-Sqs antibodyAnti-Ss antibodyAnti-Fpp -Fpp Farnesyltransferase antibodyAnti-Farnesyl-Diphosphate Farnesyltransferase antibodyAnti-Farnesyl-Diphosphate Farnesyltransferase 1 antibodyAnti-FDFT1 antibody |
Information sourced from Uniprot.org
