Anti-Recombinant-ENSA antibody [RM1E33] (STJA0023027)

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STJA0023027
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Alpha-Endosulfine is suitable for use in Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM1E33
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: WB: 1:500-1:1000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: ENSA
Gene ID: 2029
Uniprot ID: ENSA_HUMAN
Post Translational Modifications Phosphorylation at Ser-67 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A. Phosphorylated by PKA.
Function Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents.
Protein Name Alpha-Endosulfine
Arpp-19e
Database Links Reactome: R-HSA-2465910
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Alpha-Endosulfine antibody
Anti-Arpp-19e antibody
Anti-ENSA antibody

Information sourced from Uniprot.org

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