| Function | Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. |
| Protein Name | Cytochrome C Oxidase Subunit 4 Isoform 1 - MitochondrialCytochrome C Oxidase Polypeptide IvCytochrome C Oxidase Subunit Iv Isoform 1Cox Iv-1 |
| Database Links | Reactome: R-HSA-5628897Reactome: R-HSA-611105Reactome: R-HSA-9707564Reactome: R-HSA-9837999Reactome: R-HSA-9864848 |
| Cellular Localisation | Mitochondrion Inner MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Cytochrome C Oxidase Subunit 4 Isoform 1 - Mitochondrial antibodyAnti-Cytochrome C Oxidase Polypeptide Iv antibodyAnti-Cytochrome C Oxidase Subunit Iv Isoform 1 antibodyAnti-Cox Iv-1 antibodyAnti-COX4I1 antibodyAnti-COX4 antibody |
Information sourced from Uniprot.org
![Immunofluorescence analysis of NIH/3T3 cells using [KD Validated] COX IV Rabbit polyclonal antibody (STJ11104961) at dilution of 1:50 (40x lens). Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/177605/369461/STJ11104961_1__90609.1713134964.jpg?c=1 "Immunofluorescence analysis of NIH/3T3 cells using [KD Validated] COX IV Rabbit polyclonal antibody (STJ11104961) at dilution of 1:50 (40x lens). Blue: DAPI for nuclear staining.")
