| Host: | Rabbit |
| Applications: | FC/IF/IHC/IP/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal antibody anti-Recombinant-Calmodulin-1 is suitable for use in Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | RM1A96 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide |
| Purification: | Protein A/G purified from cell culture supernatant |
| Dilution Range: | FCM: 1:20-1:100, IF: 1:50-1:200, IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000 |
| Storage Instruction: | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
| Gene Symbol: | CALM1 |
| Gene ID: | 801/805/808 |
| Uniprot ID: | CALM1_HUMAN |
| Function | Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Is a regulator of voltage-dependent L-type calcium channels. Mediates calcium-dependent inactivation of CACNA1C. Positively regulates calcium-activated potassium channel activity of KCNN2. Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding. Acts as a sensor to modulate the endoplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2. (Microbial infection) Required for Legionella pneumophila SidJ glutamylase activity. (Microbial infection) Required for C.violaceum CopC and S.flexneri OspC3 arginine ADP-riboxanase activity. |
| Protein Name | Calmodulin-1 |
| Database Links | Reactome: R-HSA-111932Reactome: R-HSA-111933Reactome: R-HSA-111957Reactome: R-HSA-111997Reactome: R-HSA-114608Reactome: R-HSA-1445148Reactome: R-HSA-1474151Reactome: R-HSA-163615Reactome: R-HSA-180024Reactome: R-HSA-1855204Reactome: R-HSA-2025928Reactome: R-HSA-203615Reactome: R-HSA-2151201Reactome: R-HSA-2514859Reactome: R-HSA-2672351Reactome: R-HSA-2871809Reactome: R-HSA-4086398Reactome: R-HSA-418359Reactome: R-HSA-425561Reactome: R-HSA-438066Reactome: R-HSA-442720Reactome: R-HSA-442729Reactome: R-HSA-442982Reactome: R-HSA-445355Reactome: R-HSA-451308Reactome: R-HSA-5210891Reactome: R-HSA-5218920Reactome: R-HSA-5218921Reactome: R-HSA-5576892Reactome: R-HSA-5578775Reactome: R-HSA-5607763Reactome: R-HSA-5626467Reactome: R-HSA-5627123Reactome: R-HSA-5673000Reactome: R-HSA-5673001Reactome: R-HSA-6802946Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-70221Reactome: R-HSA-8876725Reactome: R-HSA-9009391Reactome: R-HSA-9022535Reactome: R-HSA-9022692Reactome: R-HSA-936837Reactome: R-HSA-9617324Reactome: R-HSA-9619229Reactome: R-HSA-9619483Reactome: R-HSA-9620244Reactome: R-HSA-9648002Reactome: R-HSA-9649948Reactome: R-HSA-9656223Reactome: R-HSA-9664323Reactome: R-HSA-983695 |
| Cellular Localisation | CytoplasmCytoskeletonSpindleSpindle PoleMicrotubule Organizing CenterCentrosomeCell ProjectionCiliumFlagellumDistributed Throughout The Cell During InterphaseBut During Mitosis Becomes Dramatically Localized To The Spindle Poles And The Spindle Microtubules |
| Alternative Antibody Names | Anti-Calmodulin-1 antibodyAnti-CALM1 antibodyAnti-CALM antibodyAnti-CAM antibodyAnti-CAM1 antibody |
Information sourced from Uniprot.org
