| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RBM17 |
| Gene ID: | 84991 |
| Uniprot ID: | SPF45_HUMAN |
| Immunogen Region: | 1-240 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human RBM17 (NP_116294.1). |
| Immunogen Sequence: | MSLYDDLGVETSDSKTEGWS KNFKLLQSQLQVKKAALTQA KSQRTKQSTVLAPVIDLKRG GSSDDRQIVDTPPHVAAGLK DPVPSGFSAGEVLIPLADEY DPMFPNDYEKVVKRQREERQ RQRELERQKEIEEREKRRKD RHEASGFARRPDPDSDEDED YERERRKRSMGGAAIAPPTS LVEKDKELPRDFPYEEDSRP RSQSSKAAIPPPVYEEQDRP RSPTGPSNSFLANMGGTVA |
| Function | Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia. |
| Protein Name | Splicing Factor 4545 Kda-Splicing FactorRna-Binding Motif Protein 17 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Splicing Factor 45 antibodyAnti-45 Kda-Splicing Factor antibodyAnti-Rna-Binding Motif Protein 17 antibodyAnti-RBM17 antibodyAnti-SPF45 antibody |
Information sourced from Uniprot.org