| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RAB8B (1-207) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RAB8B |
| Gene ID: |
51762 |
| Uniprot ID: |
RAB8B_HUMAN |
| Immunogen Region: |
1-207 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-207 of human RAB8B (NP_057614.1). |
| Immunogen Sequence: |
MAKTYDYLFKLLLIGDSGVG KTCLLFRFSEDAFNTTFIST IGIDFKIRTIELDGKKIKLQ IWDTAGQERFRTITTAYYRG AMGIMLVYDITNEKSFDNIK NWIRNIEEHASSDVERMILG NKCDMNDKRQVSKERGEKLA IDYGIKFLETSAKSSANVEE AFFTLARDIMTKLNRKMNDS NSAGAGGPVKITENRSKKTS FFRCSLL |
| Post Translational Modifications | Phosphorylation of Thr-72 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2. |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells. May participate in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route. |
| Protein Name | Ras-Related Protein Rab-8b |
| Database Links | Reactome: R-HSA-8854214Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideCytoplasmic VesiclePhagosomePhagosome MembraneEndosome MembraneRecruited To Phagosomes Containing SAureus Or MTuberculosisColocalized With Mical1Graf1/Arhgap26 And Graf2/Arhgap10 On Endosomal Tubules |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-8b antibodyAnti-RAB8B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
