Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-RAB12 (1-70) is suitable for use in Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | RAB12 |
Gene ID: | 201475 |
Uniprot ID: | RAB12_HUMAN |
Immunogen Region: | 1-70 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human RAB12 (NP_001020471.2). |
Immunogen Sequence: | MDPGAALQRRAGGGGGLGAG SPALSGGQGRRRKQPPRPAD FKLQVIIIGSRGVGKTSLME RFTDDTFCEA |
Post Translational Modifications | Phosphorylation of Ser-106 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2. |
Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy. |
Protein Name | Ras-Related Protein Rab-12 |
Database Links | Reactome: R-HSA-8873719 Reactome: R-HSA-8876198 |
Cellular Localisation | Recycling Endosome Membrane Lipid-Anchor Cytoplasmic Side Lysosome Membrane Golgi Apparatus Membrane Cytoplasmic Vesicle Autophagosome |
Alternative Antibody Names | Anti-Ras-Related Protein Rab-12 antibody Anti-RAB12 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance