| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PURB (213-312) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PURB |
| Gene ID: |
5814 |
| Uniprot ID: |
PURB_HUMAN |
| Immunogen Region: |
213-312 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 213-312 of human PURB (NP_150093.1). |
| Immunogen Sequence: |
GGLYGELPEGTSITVDSKRF FFDVGCNKYGVFLRVSEVKP SYRNAITVPFKAWGKFGGAF CRYADEMKEIQERQRDKLYE RRGGGSGGGEESEGEEVDED |
| Tissue Specificity | Expressed in myocardium of heart failure patients. |
| Function | Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs. |
| Protein Name | Transcriptional Activator Protein Pur-BetaPurine-Rich Element-Binding Protein B |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcriptional Activator Protein Pur-Beta antibodyAnti-Purine-Rich Element-Binding Protein B antibodyAnti-PURB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
