| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PTP4A1 (1-173) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PTP4A1 |
| Gene ID: |
7803 |
| Uniprot ID: |
TP4A1_HUMAN |
| Immunogen Region: |
1-173 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-173 of human PTP4A1 (NP_003454.1). |
| Immunogen Sequence: |
MARMNRPAPVEVTYKNMRFL ITHNPTNATLNKFIEELKKY GVTTIVRVCEATYDTTLVEK EGIHVLDWPFDDGAPPSNQI VDDWLSLVKIKFREEPGCCI AVHCVAGLGRAPVLVALALI EGGMKYEDAVQFIRQKRRGA FNSKQLLYLEKYRPKMRLRF KDSNGHRNNCCIQ |
| Tissue Specificity | Expressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines. |
| Post Translational Modifications | Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus. |
| Function | Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. |
| Protein Name | Protein Tyrosine Phosphatase Type Iva 1Ptp(CaaxiProtein-Tyrosine Phosphatase 4a1Protein-Tyrosine Phosphatase Of Regenerating Liver 1Prl-1 |
| Cellular Localisation | Cell MembraneLipid-AnchorEarly EndosomeEndoplasmic ReticulumCytoplasmCytoskeletonSpindleNucleusAnd Mitotic Spindle |
| Alternative Antibody Names | Anti-Protein Tyrosine Phosphatase Type Iva 1 antibodyAnti-Ptp(Caaxi antibodyAnti-Protein-Tyrosine Phosphatase 4a1 antibodyAnti-Protein-Tyrosine Phosphatase Of Regenerating Liver 1 antibodyAnti-Prl-1 antibodyAnti-PTP4A1 antibodyAnti-PRL1 antibodyAnti-PTPCAAX1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
