| Tissue Specificity | Highly concentrated in brain, lung and intestinal mucosa. |
| Post Translational Modifications | Myristoylation mediates membrane localization. |
| Function | Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum. Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863. Acts as a regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation. |
| Protein Name | Cgmp-Dependent Protein Kinase 2Cgk 2Cgk2Cgmp-Dependent Protein Kinase IiCgkii |
| Database Links | Reactome: R-HSA-1474151Reactome: R-HSA-4086398Reactome: R-HSA-418457Reactome: R-HSA-9648002 |
| Cellular Localisation | Apical Cell MembraneLipid-Anchor |
| Alternative Antibody Names | Anti-Cgmp-Dependent Protein Kinase 2 antibodyAnti-Cgk 2 antibodyAnti-Cgk2 antibodyAnti-Cgmp-Dependent Protein Kinase Ii antibodyAnti-Cgkii antibodyAnti-PRKG2 antibodyAnti-PRKGR2 antibody |
Information sourced from Uniprot.org
