| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PPP3CB (286-525) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PPP3CB |
| Gene ID: |
5532 |
| Uniprot ID: |
PP2BB_HUMAN |
| Immunogen Region: |
286-525 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 286-525 of human PPP3CB (NP_001135825.1). |
| Immunogen Sequence: |
IIRAHEAQDAGYRMYRKSQT TGFPSLITIFSAPNYLDVYN NKAAVLKYENNVMNIRQFNC SPHPYWLPNFMDVFTWSLPF VGEKVTEMLVNVLSICSDDE LMTEGEDQFDVGSAAARKEI IRNKIRAIGKMARVFSVLRE ESESVLTLKGLTPTGMLPSG VLAGGRQTLQSATVEAIEAE KAIRGFSPPHRICSFEEAKG LDRINERMPPRKDAVQQDGF NSLNTAHATENHGTGNHTA |
| Function | Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates TFEB in response to lysosomal Ca(2+) release, resulting in TFEB nuclear translocation and stimulation of lysosomal biogenesis. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. Negatively regulates MAP3K14/NIK signaling via inhibition of nuclear translocation of the transcription factors RELA and RELB. May play a role in skeletal muscle fiber type specification. |
| Protein Name | Serine/Threonine-Protein Phosphatase 2b Catalytic Subunit Beta IsoformCam-Prp Catalytic SubunitCalmodulin-Dependent Calcineurin A Subunit Beta IsoformCna Beta |
| Database Links | Reactome: R-HSA-180024Reactome: R-HSA-2025928Reactome: R-HSA-2871809Reactome: R-HSA-4086398Reactome: R-HSA-5607763Reactome: R-HSA-9010642 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase 2b Catalytic Subunit Beta Isoform antibodyAnti-Cam-Prp Catalytic Subunit antibodyAnti-Calmodulin-Dependent Calcineurin A Subunit Beta Isoform antibodyAnti-Cna Beta antibodyAnti-PPP3CB antibodyAnti-CALNA2 antibodyAnti-CALNB antibodyAnti-CNA2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
