| Tissue Specificity | Brain. |
| Function | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity. Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance. |
| Protein Name | Serine/Threonine-Protein Phosphatase 2a 55 Kda Regulatory Subunit B Beta IsoformPp2a Subunit B Isoform B55-BetaPp2a Subunit B Isoform Pr55-BetaPp2a Subunit B Isoform R2-BetaPp2a Subunit B Isoform Beta |
| Cellular Localisation | Isoform 1: CytoplasmCytoplasmCytoskeletonMembraneIsoform 2: CytoplasmMitochondrionMitochondrion Outer MembraneUnder Basal ConditionsLocalizes To Both Cytosolic And Mitochondrial CompartmentsRelocalizes From The Cytosolic To The Mitochondrial Compartment During ApoptosisIts Targeting To The Outer Mitochondrial Membrane (Omm) Involves An Association With Import Receptors Of The Tom Complex And Is Required To Promote Proapoptotic Activity |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase 2a 55 Kda Regulatory Subunit B Beta Isoform antibodyAnti-Pp2a Subunit B Isoform B55-Beta antibodyAnti-Pp2a Subunit B Isoform Pr55-Beta antibodyAnti-Pp2a Subunit B Isoform R2-Beta antibodyAnti-Pp2a Subunit B Isoform Beta antibodyAnti-PPP2R2B antibody |
Information sourced from Uniprot.org
