| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PNRC2 (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PNRC2 |
| Gene ID: |
55629 |
| Uniprot ID: |
PNRC2_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PNRC2 (NP_060231.1). |
| Immunogen Sequence: |
MGGGERYNIPAPQSRNVSKN QQQLNRQKTKEQNSQMKIVH KKKERGHGYNSSAAAWQAMQ NGGKNKNFPNNQSWNSSLSG PRLLFKSQANQNYAGAKFSE |
| Tissue Specificity | Expressed in heart, lung, muscle and brain. |
| Function | Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for UPF1/RENT1 localization to the P-body. Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Also acts as a nuclear receptor coactivator. May play a role in controlling the energy balance between energy storage and energy expenditure. |
| Protein Name | Proline-Rich Nuclear Receptor Coactivator 2 |
| Database Links | Reactome: R-HSA-975957 |
| Cellular Localisation | NucleusCytoplasmP-Body |
| Alternative Antibody Names | Anti-Proline-Rich Nuclear Receptor Coactivator 2 antibodyAnti-PNRC2 antibodyAnti-HSPC208 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
