| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PLIN5 (270-463) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PLIN5 |
| Gene ID: |
440503 |
| Uniprot ID: |
PLIN5_HUMAN |
| Immunogen Region: |
270-463 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 270-463 of human PLIN5 (NP_001013728.2). |
| Immunogen Sequence: |
PPESRRRSQAELETLVLSRS LTQELQGTVEALESSVRGLP AGAQEKVAEVRRSVDALQTA FADARCFRDVPAAALAEGRG RVAHAHACVDELLELVVQAV PLPWLVGPFAPILVERPEPL PDLADLVDEVIGGPDPRWAH LDWPAQQRAWEAEHRDGSGN GDGDRMGVAGDICEQEPETP SCPVKHTLMPELDF |
| Tissue Specificity | Expressed in skeletal muscle, liver, heart and kidney. |
| Post Translational Modifications | Phosphorylated by PKA. Phosphorylated on serine in skeletal muscle at rest or upon lipolytic stimulation. |
| Function | Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE. |
| Protein Name | Perilipin-5Lipid Storage Droplet Protein 5 |
| Cellular Localisation | Lipid DropletCytoplasmMitochondrionLipid Droplet Surface-AssociatedExchanges Between Lipid Droplets And The Cytoplasm |
| Alternative Antibody Names | Anti-Perilipin-5 antibodyAnti-Lipid Storage Droplet Protein 5 antibodyAnti-PLIN5 antibodyAnti-LSDP5 antibodyAnti-OXPAT antibodyAnti-PAT-1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
