| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PLIN1 (400-500) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PLIN1 |
| Gene ID: |
5346 |
| Uniprot ID: |
PLIN1_HUMAN |
| Immunogen Region: |
400-500 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 400-500 of human Perilipin A (NP_002657.3). |
| Immunogen Sequence: |
HYVPLPRLSLMEPESEFRDI DNPPAEVERREAERRASGAP SAGPEPAPRLAQPRRSLRSA QSPGAPPGPGLEDEVATPAA PRPGFPAVPREKPKRRVSDS F |
| Tissue Specificity | Detected in adipocytes from white adipose tissue (at protein level). Detected in visceral adipose tissue and mammary gland. |
| Post Translational Modifications | Major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet. |
| Function | Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. |
| Protein Name | Perilipin-1Lipid Droplet-Associated Protein |
| Database Links | Reactome: R-HSA-163560Reactome: R-HSA-381340Reactome: R-HSA-9031528 |
| Cellular Localisation | Endoplasmic ReticulumLipid DropletLipid Droplet Surface-Associated |
| Alternative Antibody Names | Anti-Perilipin-1 antibodyAnti-Lipid Droplet-Associated Protein antibodyAnti-PLIN1 antibodyAnti-PERI antibodyAnti-PLIN antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
