| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PLA2G16 (68-162) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PLAAT3 |
| Gene ID: |
11145 |
| Uniprot ID: |
PLAT3_HUMAN |
| Immunogen Region: |
68-162 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 68-162 of human PLA2G16 (NP_009000.2). |
| Immunogen Sequence: |
VAGSDKYQVNNKHDDKYSPL PCSKIIQRAEELVGQEVLYK LTSENCEHFVNELRYGVARS DQVRDVIIAASVAGMGLAAM SLIGVMFSRNKRQKQ |
| Tissue Specificity | Widely expressed. low expression, if any, in hematopoietic cells and thymus. In testis, confined to round spermatids. Expressed in normal ovarian epithelial cells. Down-regulated in some ovarian carcinomas and testicular germ cell tumors. Highly expressed in white adipose tissue. |
| Function | Exhibits both phospholipase A1/2 and acyltransferase activities. Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids. For most substrates, PLA1 activity is much higher than PLA2 activity. Shows O-acyltransferase activity,catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid. Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs). Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity. Required for complete organelle rupture and degradation that occur during eye lens terminal differentiation, when fiber cells that compose the lens degrade all membrane-bound organelles in order to provide lens with transparency to allow the passage of light. Organelle membrane degradation is probably catalyzed by the phospholipase activity. (Microbial infection) Acts as a host factor for picornaviruses: required during early infection to promote viral genome release into the cytoplasm. May act as a cellular sensor of membrane damage at sites of virus entry, which relocalizes to sites of membrane rupture upon virus unfection. Facilitates safe passage of the RNA away from LGALS8, enabling viral genome translation by host ribosome. May also be involved in initiating pore formation, increasing pore size or in maintaining pores for genome delivery. The lipid-modifying enzyme activity is required for this process. |
| Protein Name | Phospholipase A And Acyltransferase 3 Adipose-Specific Phospholipase A2AdplaGroup Xvi Phospholipase A1/A2H-Rev 107 Protein HomologH-Rev107Hrev107-1Hras-Like Suppressor 1Hras-Like Suppressor 3Hrsl3Hrev107-3Renal Carcinoma Antigen Ny-Ren-65 |
| Database Links | Reactome: R-HSA-1482788Reactome: R-HSA-1482801Reactome: R-HSA-1482839Reactome: R-HSA-1482922 |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinCytoplasmCytosolPerinuclear RegionPeroxisome MembraneMitochondrion MembraneNucleus EnvelopeLysosome MembraneEndoplasmic Reticulum MembraneDuring Eye Lens DifferentiationRecruited From The Cytosol To Various OrganellesIncluding MitochondriaEndoplasmic ReticulumNuclear Envelope And LysosomesImmediately Before Organelle DegradationThis Translocation Is Triggered By Organelle Membrane Damage And Requires The C-Terminal Transmembrane Domain |
| Alternative Antibody Names | Anti-Phospholipase A And Acyltransferase 3 antibodyAnti-Adipose-Specific Phospholipase A2 antibodyAnti-Adpla antibodyAnti-Group Xvi Phospholipase A1/A2 antibodyAnti-H-Rev 107 Protein Homolog antibodyAnti-H-Rev107 antibodyAnti-Hrev107-1 antibodyAnti-Hras-Like Suppressor 1 antibodyAnti-Hras-Like Suppressor 3 antibodyAnti-Hrsl3 antibodyAnti-Hrev107-3 antibodyAnti-Renal Carcinoma Antigen Ny-Ren-65 antibodyAnti-PLAAT3 antibodyAnti-HRASLS3 antibodyAnti-HREV107 antibodyAnti-PLA2G16 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
