| Tissue Specificity | Ubiquitously expressed in all tissues examined. Isoform 2 is expressed at higher levels in the ovary than is isoform 1. |
| Post Translational Modifications | Dual phosphorylation of Thr-244 and Thr-249 activates the kinase. Phosphorylation of Thr-379 activates the kinase. Phosphorylated upon arsenic trioxide As(2)O(3) treatment. Phosphorylated by MAPK1/ERK2, MAPK11 and MAPK14. Dephosphorylated by PP2A. |
| Function | Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. |
| Protein Name | Map Kinase-Interacting Serine/Threonine-Protein Kinase 2Map Kinase Signal-Integrating Kinase 2Mapk Signal-Integrating Kinase 2Mnk2 |
| Cellular Localisation | Isoform 2: NucleusPml BodyIsoform 1: Cytoplasm |
| Alternative Antibody Names | Anti-Map Kinase-Interacting Serine/Threonine-Protein Kinase 2 antibodyAnti-Map Kinase Signal-Integrating Kinase 2 antibodyAnti-Mapk Signal-Integrating Kinase 2 antibodyAnti-Mnk2 antibodyAnti-MKNK2 antibodyAnti-GPRK7 antibodyAnti-MNK2 antibody |
Information sourced from Uniprot.org
