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Anti-Phospho-CDKN2A-Ser326 antibody (107-156 aa) (STJ90987)

Western blot analysis of lysates from HeLa cells treated with EPO 20U/ml 15', using p16-INK4a (Phospho-Ser152) Antibody. The lane on the right is blocked with the phospho peptide.
Western blot analysis of 22RV1 HELA cells using Phospho-p16 (S326) Polyclonal Antibody diluted at 1：500
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using p16-INK4a (Phospho-Ser152) Antibody. The picture on the right is blocked with the phospho peptide.
Western blot analysis of JK cells using Phospho-p16 (S326) Polyclonal Antibody diluted at 1：500

Anti-Phospho-CDKN2A-Ser326 antibody (107-156 aa) (STJ90987)

SKU:

STJ90987

$62.10 - $305.10

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General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Rabbit
Applications:	WB/IHC/IF/ELISA
Reactivity:	Human/Rat/Mouse
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Phospho-Cyclin-dependent kinase inhibitor 2A-Ser326 (107-156 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:5000 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	CDKN2A
Gene ID:	1029
Uniprot ID:	CDN2A_HUMAN
Immunogen Region:	107-156 aa
Specificity:	Phospho-p16 (S326) Polyclonal Antibody detects endogenous levels of p16 protein only when phosphorylated at S326.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human p16-INK4a around the phosphorylation site of Ser152 at the amino acid range 107-156

Post Translational Modifications	Phosphorylation seems to increase interaction with CDK4.
Function	Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.
Protein Name	Cyclin-Dependent Kinase Inhibitor 2a Cyclin-Dependent Kinase 4 Inhibitor A Cdk4i Multiple Tumor Suppressor 1 Mts-1 P16-Ink4a P16-Ink4 P16ink4a
Database Links	Reactome: R-HSA-111471 Reactome: R-HSA-2559580 Reactome: R-HSA-2559585 Reactome: R-HSA-3108214 Reactome: R-HSA-3232118 Reactome: R-HSA-6804757 Reactome: R-HSA-69541 Reactome: R-HSA-8941858 Reactome: R-HSA-9645722 Reactome: R-HSA-9646303 Reactome: R-HSA-9646304 Reactome: R-HSA-9759194 Reactome: R-HSA-2559582 Reactome: R-HSA-69231 Reactome: R-HSA-8853884 Reactome: R-HSA-9630791 Reactome: R-HSA-9630794 Reactome: R-HSA-9632697 Reactome: R-HSA-9632700
Cellular Localisation	Cytoplasm Nucleus
Alternative Antibody Names	Anti-Cyclin-Dependent Kinase Inhibitor 2a antibody Anti-Cyclin-Dependent Kinase 4 Inhibitor A antibody Anti-Cdk4i antibody Anti-Multiple Tumor Suppressor 1 antibody Anti-Mts-1 antibody Anti-P16-Ink4a antibody Anti-P16-Ink4 antibody Anti-P16ink4a antibody Anti-CDKN2A antibody Anti-CDKN2 antibody Anti-MTS1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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