| Tissue Specificity | Expressed at high levels in normal skin but decreased in keratinocytes from toxic epidermal necrolysis (TEN) patients (at protein level). |
| Post Translational Modifications | Phosphorylation by IRAK1 and IRAK4 enhances its E3 ligase activity. Phosphorylated by ATM in response to DNA damage, promoting localization to DNA double-strand breaks (DSBs) and ability to mediate 'Lys-63'-linked ubiquitination of NBN. Sumoylated. |
| Function | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Acts as a positive regulator of inflammatory response in microglia through activation of NF-kappa-B and MAP kinase. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation. Conjugates 'Lys-63'-linked ubiquitin chains to the adapter protein ASC/PYCARD, which in turn is crucial for NLRP3 inflammasome activation. Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation.preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3. Negatively regulates necroptosis by reducing RIPK3 expression. Mediates 'Lys-63'-linked ubiquitination of RIPK1. Following phosphorylation by ATM, catalyzes 'Lys-63'-linked ubiquitination of NBN, promoting DNA repair via homologous recombination. Negatively regulates activation of the metabolic mTORC1 signaling pathway by mediating 'Lys-63'-linked ubiquitination of mTORC1-inhibitory protein TSC1 and thereby promoting TSC1/TSC2 complex stability. |
| Protein Name | E3 Ubiquitin-Protein Ligase Pellino Homolog 1Pellino-1Pellino-Related Intracellular-Signaling MoleculeRing-Type E3 Ubiquitin Transferase Pellino Homolog 1 |
| Database Links | Reactome: R-HSA-5675482Reactome: R-HSA-9020702Reactome: R-HSA-937039Reactome: R-HSA-975144 |
| Cellular Localisation | ChromosomeLocalizes To Dna Double-Strand Breaks (Dsbs) In Response To Dna Damage |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Pellino Homolog 1 antibodyAnti-Pellino-1 antibodyAnti-Pellino-Related Intracellular-Signaling Molecule antibodyAnti-Ring-Type E3 Ubiquitin Transferase Pellino Homolog 1 antibodyAnti-PELI1 antibodyAnti-PRISM antibody |
Information sourced from Uniprot.org
