| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-OAS2 (600-700) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
OAS2 |
| Gene ID: |
4939 |
| Uniprot ID: |
OAS2_HUMAN |
| Immunogen Region: |
600-700 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 600-700 of human OAS2 (NP_058197.2). |
| Immunogen Sequence: |
TQYQQLCIFWKVNYNFEDET VRKFLLSQLQKTRPVILDPA EPTGDVGGGDRWCWHLLAKE AKEWLSSPCFKDGTGNPIPP WKVPTMQTPGSCGARIHPIV N |
| Post Translational Modifications | Myristoylation is not essential for its activity. Glycosylated. Glycosylation is essential for its activity. |
| Function | Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation. Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNASEL-dependent pathway or an alternative antiviral pathway independent of RNASEL. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. May act as a negative regulator of lactation, stopping lactation in virally infected mammary gland lobules, thereby preventing transmission of viruses to neonates. Non-infected lobules would not be affected, allowing efficient pup feeding during infection. |
| Protein Name | 2'-5'-Oligoadenylate Synthase 2(2-5'Oligo(A Synthase 22-5a Synthase 2P69 Oas / P71 OasP69oas / P71oas |
| Database Links | Reactome: R-HSA-877300Reactome: R-HSA-8983711Reactome: R-HSA-909733 |
| Cellular Localisation | CytoplasmPerinuclear Region |
| Alternative Antibody Names | Anti-2'-5'-Oligoadenylate Synthase 2 antibodyAnti-(2-5'Oligo(A Synthase 2 antibodyAnti-2-5a Synthase 2 antibodyAnti-P69 Oas / P71 Oas antibodyAnti-P69oas / P71oas antibodyAnti-OAS2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
