| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NVL (340-520) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NVL |
| Gene ID: |
4931 |
| Uniprot ID: |
NVL_HUMAN |
| Immunogen Region: |
340-520 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 340-520 of human NVL (NP_001230076.1). |
| Immunogen Sequence: |
CLGIPDEASRERILQTLCRK LRLPQAFDFCHLAHLTPGFV GADLMALCREAAMCAVNRVL MKLQEQQKKNPEMEDLPSKG VQEERLGTEPTSETQDELQR LLGLLRDQDPLSEEQMQGLC IELNDFIVALSSVQPSAKRE GFVTVPNVTWADIGALEDIR EELTMAILAPVRNPDQFKAL G |
| Tissue Specificity | Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina. |
| Function | Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways. Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus. Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity. |
| Protein Name | Nuclear Valosin-Containing Protein-LikeNvlpNuclear Vcp-Like Protein |
| Cellular Localisation | Isoform 2: NucleusNucleoplasmIsoform 1: NucleusNucleolusNucleusExpressed Predominantly In The NucleolusAssociates With Pre-Ribosomal Particles In The Nucleus |
| Alternative Antibody Names | Anti-Nuclear Valosin-Containing Protein-Like antibodyAnti-Nvlp antibodyAnti-Nuclear Vcp-Like Protein antibodyAnti-NVL antibodyAnti-NVL2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
