| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TYR (20-340) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TYR |
| Gene ID: |
7299 |
| Uniprot ID: |
TYRO_HUMAN |
| Immunogen Region: |
20-340 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 20-340 of human Tyrosinase (NP_000363.1). |
| Immunogen Sequence: |
FPRACVSSKNLMEKECCPPW SGDRSPCGQLSGRGSCQNIL LSNAPLGPQFPFTGVDDRES WPSVFYNRTCQCSGNFMGFN CGNCKFGFWGPNCTERRLLV RRNIFDLSAPEKDKFFAYLT LAKHTISSDYVIPIGTYGQM KNGSTPMFNDINIYDLFVWM HYYVSMDALLGGSEIWRDID FAHEAPAFLPWHRLFLLRWE QEIQKLTGDENFTIPYWDWR DAEKCDICTDEYMGGQHPT |
| Post Translational Modifications | Glycosylated. |
| Function | This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. |
| Protein Name | TyrosinaseLb24-AbMonophenol MonooxygenaseSk29-AbTumor Rejection Antigen Ab |
| Database Links | Reactome: R-HSA-5662702 |
| Cellular Localisation | Melanosome MembraneSingle-Pass Type I Membrane ProteinMelanosomeProper Trafficking To Melanosome Is Regulated By Sgsm2Ankrd27Rab9aRab32 And Rab38 |
| Alternative Antibody Names | Anti-Tyrosinase antibodyAnti-Lb24-Ab antibodyAnti-Monophenol Monooxygenase antibodyAnti-Sk29-Ab antibodyAnti-Tumor Rejection Antigen Ab antibodyAnti-TYR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
