| Post Translational Modifications | Ubiquitinated. |
| Function | RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair. MAGEF1-NSMCE1 ubiquitin ligase promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors. |
| Protein Name | Non-Structural Maintenance Of Chromosomes Element 1 HomologNon-Smc Element 1 Homolog |
| Database Links | Reactome: R-HSA-3108214 |
| Cellular Localisation | NucleusChromosomeTelomere |
| Alternative Antibody Names | Anti-Non-Structural Maintenance Of Chromosomes Element 1 Homolog antibodyAnti-Non-Smc Element 1 Homolog antibodyAnti-NSMCE1 antibodyAnti-HSPC333 antibodyAnti-HSPC337 antibody |
Information sourced from Uniprot.org
