• Western blot analysis of extracts of various cell lines, using NPR1 antibody (STJ112475) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 40s.

Anti-NPR1 antibody (260-470) (STJ112475)

SKU:
STJ112475

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-NPR1 (260-470) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NPR1
Gene ID: 4881
Uniprot ID: ANPRA_HUMAN
Immunogen Region: 260-470
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 260-470 of human NPR1 (NP_000897.3).
Immunogen Sequence: EAGLCGEDYVFFHLDIFGQS LQGGQGPAPRRPWERGDGQD VSARQAFQAAKIITYKDPDN PEYLEFLKQLKHLAYEQFNF TMEDGLVNTIPASFHDGLLL YIQAVTETLAHGGTVTDGEN ITQRMWNRSFQGVTGYLKID SSGDRETDFSLWDMDPENGA FRVVLNYNGTSQELVAVSGR KLNWPLGYPPPDIPKCGFDN EDPACNQDHLS
Post Translational Modifications Phosphorylation of the protein kinase-like domain is required for full activation by ANP.
Function Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.
Protein Name Atrial Natriuretic Peptide Receptor 1
Atrial Natriuretic Peptide Receptor Type A
Anp-A
Anpr-A
Npr-A
Guanylate Cyclase A
Gc-A
Database Links Reactome: R-HSA-5578768
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Atrial Natriuretic Peptide Receptor 1 antibody
Anti-Atrial Natriuretic Peptide Receptor Type A antibody
Anti-Anp-A antibody
Anti-Anpr-A antibody
Anti-Npr-A antibody
Anti-Guanylate Cyclase A antibody
Anti-Gc-A antibody
Anti-NPR1 antibody
Anti-ANPRA antibody

Information sourced from Uniprot.org

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