| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NMB (1-121) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NMB |
| Gene ID: |
4828 |
| Uniprot ID: |
NMB_HUMAN |
| Immunogen Region: |
1-121 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-121 of human NMB (NP_066563.2). |
| Immunogen Sequence: |
MARRAGGARMFGSLLLFALL AAGVAPLSWDLPEPRSRASK IRVHSRGNLWATGHFMGKKS LEPSSPSPLGTAPHTSLRDQ RLQLSHDLLGILLLKKALGV SLSRPAPQIQYRRLLVQILQ K |
| Function | Stimulates smooth muscle contraction. Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity. Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem. These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response. Contributes to induction of acute itch, possibly through activation of the NMBR receptor on dorsal root ganglion neurons. Increases expression of NMBR and steroidogenic mediators STAR, CYP11A1 and HSD3B1 in Leydig cells, induces secretion of testosterone by Leydig cells and also promotes Leydig cell proliferation. Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6. Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R. |
| Protein Name | Neuromedin-B Cleaved Into - Neuromedin-B-32 - Neuromedin-B |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476 |
| Cellular Localisation | SecretedCell ProjectionNeuron ProjectionIn Neurons Of The Retrotrapezoid Nucleus//Parafacial Respiratory GroupExpressed On Neuron Projections Which Project Into The Pre-Botzinger Complex |
| Alternative Antibody Names | Anti-Neuromedin-B Cleaved Into - Neuromedin-B-32 - Neuromedin-B antibodyAnti-NMB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
