| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NIT1 (1-150) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NIT1 |
| Gene ID: |
4817 |
| Uniprot ID: |
NIT1_HUMAN |
| Immunogen Region: |
1-150 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human NIT1 (NP_001172021.1). |
| Immunogen Sequence: |
MLGFITRPPHRFLSLLCPGL RIPQLSVLCAQPRPRAMAIS SSSCELPLVAVCQVTSTPDK QQNFKTCAELVREAARLGAC LAFLPEAFDFIARDPAETLH LSEPLGGKLLEEYTQLAREC GLWLSLGGFHERGQDWEQTQ KIYNCHVLLN |
| Tissue Specificity | Detected in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. |
| Function | Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells.this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. |
| Protein Name | Deaminated Glutathione AmidaseDgsh AmidaseNitrilase Homolog 1 |
| Cellular Localisation | Isoform 2: MitochondrionIsoform 1: Cytoplasm |
| Alternative Antibody Names | Anti-Deaminated Glutathione Amidase antibodyAnti-Dgsh Amidase antibodyAnti-Nitrilase Homolog 1 antibodyAnti-NIT1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
