| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NHS (600-900) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NHS |
| Gene ID: |
4810 |
| Uniprot ID: |
NHS_HUMAN |
| Immunogen Region: |
600-900 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 600-900 of human NHS (NP_938011.1). |
| Immunogen Sequence: |
MDQKDDHQSSSGNWSGSSST CPSQTSETIPPAASPPLTGS SHCDSELSLNTAPHANEDAS VFVTEQYNDHLDKVRGHRAN SFTSTVADLLDDPNNSNTSD SEWNYLHHHHDASCRQDFSP ERPKADSLGCPSFTSMATYD SFLEKSPSDKADTSSHFSVD TEGYYTSMHFDCGLKGNKSY VCHYAALGPENGQGVGASPG LPDCAWQDYLDHKRQGRPSI SFRKPKAKPTPPKRSSSLR |
| Tissue Specificity | Detected at low levels in all tissues analyzed. Detected in fetal and adult brain, lens, retina, retinal pigment epithelium, placenta, lymphocytes and fibroblasts. Levels in retinal pigment epithelium, placenta, lymphocytes, and fibroblasts are very low. Expressed also in kidney, lung and thymus. |
| Function | May function in cell morphology by maintaining the integrity of the circumferential actin ring and controlling lamellipod formation. Involved in the regulation eye, tooth, brain and craniofacial development. |
| Protein Name | Actin Remodeling Regulator NhsCongenital Cataracts And Dental Anomalies ProteinNance-Horan Syndrome Protein |
| Database Links | Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013423 |
| Cellular Localisation | Isoform 1: Apical Cell MembranePeripheral Membrane ProteinCell ProjectionLamellipodiumCell JunctionTight JunctionFocal AdhesionColocalizes With The Tight Junction Protein Tjp1 In Epithelial CellsLocalizes To The Leading Edge Of Lamellipodia In Motile CellsIsoform 3: Cytoplasm |
| Alternative Antibody Names | Anti-Actin Remodeling Regulator Nhs antibodyAnti-Congenital Cataracts And Dental Anomalies Protein antibodyAnti-Nance-Horan Syndrome Protein antibodyAnti-NHS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
