| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NHP2L1 (1-128) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SNU13 |
| Gene ID: |
4809 |
| Uniprot ID: |
NH2L1_HUMAN |
| Immunogen Region: |
1-128 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-128 of human NHP2L1 (NP_004999.1). |
| Immunogen Sequence: |
MTEADVNPKAYPLADAHLTK KLLDLVQQSCNYKQLRKGAN EATKTLNRGISEFIVMAADA EPLEIILHLPLLCEDKNVPY VFVRSKQALGRACGVSRPVI ACSVTIKEGSQLKQQIQSIQ QSIERLLV |
| Tissue Specificity | Ubiquitous. |
| Function | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. |
| Protein Name | Nhp2-Like Protein 1High Mobility Group-Like Nuclear Protein 2 Homolog 1Otk27Snu13 HomologHsnu13U4/U6.U5 Small Nuclear Ribonucleoprotein Snu13U4/U6.U5 Tri-Snrnp 15.5 Kda Protein Cleaved Into - Nhp2-Like Protein 1 - N-Terminally Processed |
| Database Links | Reactome: R-HSA-6790901Reactome: R-HSA-6791226Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusNucleolusConcentrated In The Dense Fibrillar Component Of The Nucleolus |
| Alternative Antibody Names | Anti-Nhp2-Like Protein 1 antibodyAnti-High Mobility Group-Like Nuclear Protein 2 Homolog 1 antibodyAnti-Otk27 antibodyAnti-Snu13 Homolog antibodyAnti-Hsnu13 antibodyAnti-U4/U6.U5 Small Nuclear Ribonucleoprotein Snu13 antibodyAnti-U4/U6.U5 Tri-Snrnp 15.5 Kda Protein Cleaved Into - Nhp2-Like Protein 1 - N-Terminally Processed antibodyAnti-SNU13 antibodyAnti-NHP2L1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and Histone H2A. Z knockout (KO) 293T cells, using [KO Validated] Histone H2A. Z Rabbit polyclonal antibody (STJ114316) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/93438/374520/STJ114316_1__91357.1713141034.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and Histone H2A. Z knockout (KO) 293T cells, using [KO Validated] Histone H2A. Z Rabbit polyclonal antibody (STJ114316) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")
![Western blot analysis of lysates from wild type (WT) and Histone H2A. Z knockout (KO) 293T cells, using [KO Validated] Histone H2A. Z Rabbit polyclonal antibody (STJ28697) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/101960/390279/STJ28697_1__53499.1713160268.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and Histone H2A. Z knockout (KO) 293T cells, using [KO Validated] Histone H2A. Z Rabbit polyclonal antibody (STJ28697) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")