| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NABP2 (122-211) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NABP2 |
| Gene ID: |
79035 |
| Uniprot ID: |
SOSB1_HUMAN |
| Immunogen Region: |
122-211 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 122-211 of human NABP2 (Q9BQ15). |
| Immunogen Sequence: |
NKAVQNDSNPSASQPTTGPS AASPASENQNGNGLSAPPGP GGGPHPPHTPSHPPSTRITR SQPNHTPAGPPGPSSNPVSN GKETRRSSKR |
| Post Translational Modifications | Phosphorylated by ATM in response to DNA damage. Phosphorylation prevents degradation by the proteasome, hence stabilization of the protein and accumulation within cells. Ubiquitinated in a FBXL5-dependent manner, leading to proteasomal degradation. |
| Function | Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. |
| Protein Name | Soss Complex Subunit B1Nucleic Acid-Binding Protein 2Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protein 2bSensor Of Single-Strand Dna Complex Subunit B1Sensor Of Ssdna Subunit B1Soss-B1Single-Stranded Dna-Binding Protein 1Hssb1 |
| Database Links | Reactome: R-HSA-6807505 |
| Cellular Localisation | NucleusLocalizes To Nuclear Foci Following Dna DamageFoci Formation Is Not Cell-Cycle DependentPartial Colocalization With Rad51 After Ionizing Radiation Treatment |
| Alternative Antibody Names | Anti-Soss Complex Subunit B1 antibodyAnti-Nucleic Acid-Binding Protein 2 antibodyAnti-Oligonucleotide/Oligosaccharide-Binding Fold-Containing Protein 2b antibodyAnti-Sensor Of Single-Strand Dna Complex Subunit B1 antibodyAnti-Sensor Of Ssdna Subunit B1 antibodyAnti-Soss-B1 antibodyAnti-Single-Stranded Dna-Binding Protein 1 antibodyAnti-Hssb1 antibodyAnti-NABP2 antibodyAnti-OBFC2B antibodyAnti-SSB1 antibodyAnti-LP3587 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
