| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MUL1 |
| Gene ID: |
79594 |
| Uniprot ID: |
MUL1_HUMAN |
| Immunogen Region: |
1-352 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-352 of human MUL1 (NP_078820.2). |
| Immunogen Sequence: |
MESGGRPSLCQFILLGTTSV VTAALYSVYRQKARVSQELK GAKKVHLGEDLKSILSEAPG KCVPYAVIEGAVRSVKETLN SQFVENCKGVIQRLTLQEHK MVWNRTTHLWNDCSKIIHQR TNTVPFDLVPHEDGVDVAVR VLKPLDSVDLGLETVYEKFH PSIQSFTDVIGHYISGERPK GIQETEEMLKVGATLTGVGE LVLDNNSVRLQPPKQGMQYY LSSQDFDSLLQRQESSVRL |
| Tissue Specificity | Widely expressed with highest levels in the heart, skeletal muscle, placenta, kidney and liver. Barely detectable in colon and thymus. |
| Post Translational Modifications | Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. |
| Function | Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteasomal degradation. Mediates polyubiquitination of cytoplasmic TP53 at 'Lys-24' which targets TP53 for proteasomal degradation, thus reducing TP53 levels in the cytoplasm and mitochondrion. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology by promoting mitochondrial fragmentation, and influences mitochondrial localization. Likely to promote mitochondrial fission through negatively regulating the mitochondrial fusion proteins MFN1 and MFN2, acting in a pathway that is parallel to the PRKN/PINK1 regulatory pathway. May also be involved in the sumoylation of the membrane fission protein DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting RIGI-dependent antiviral response. Can mediate RIGI sumoylation and disrupt its polyubiquitination. |
| Protein Name | Mitochondrial Ubiquitin Ligase Activator Of Nfkb 1E3 Sumo-Protein Ligase Mul1E3 Ubiquitin-Protein Ligase Mul1Growth Inhibition And Death E3 LigaseMitochondrial-Anchored Protein LigaseProtein HadesPutative Nf-Kappa-B-Activating Protein 266Ring Finger Protein 218Ring-Type E3 Ubiquitin Transferase Nfkb 1 |
| Database Links | Reactome: R-HSA-5689880Reactome: R-HSA-8951664Reactome: R-HSA-9755511 |
| Cellular Localisation | Mitochondrion Outer MembraneMulti-Pass Membrane ProteinPeroxisomeTransported In Mitochondrion-Derived Vesicles From The Mitochondrion To The Peroxisome |
| Alternative Antibody Names | Anti-Mitochondrial Ubiquitin Ligase Activator Of Nfkb 1 antibodyAnti-E3 Sumo-Protein Ligase Mul1 antibodyAnti-E3 Ubiquitin-Protein Ligase Mul1 antibodyAnti-Growth Inhibition And Death E3 Ligase antibodyAnti-Mitochondrial-Anchored Protein Ligase antibodyAnti-Protein Hades antibodyAnti-Putative Nf-Kappa-B-Activating Protein 266 antibodyAnti-Ring Finger Protein 218 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Nfkb 1 antibodyAnti-MUL1 antibodyAnti-C1orf166 antibodyAnti-GIDE antibodyAnti-MAPL antibodyAnti-MULAN antibodyAnti-RNF218 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
