| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MTR (1056-1265) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MTR |
| Gene ID: |
4548 |
| Uniprot ID: |
METH_HUMAN |
| Immunogen Region: |
1056-1265 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1056-1265 of human MTR (NP_000245.2). |
| Immunogen Sequence: |
AEPIATFYGLRQQAEKDSAS TEPYYCLSDFIAPLHSGIRD YLGLFAVACFGVEELSKAYE DDGDDYSSIMVKALGDRLAE AFAEELHERVRRELWAYCGS EQLDVADLRRLRYKGIRPAP GYPSQPDHTEKLTMWRLADI EQSTGIRLTESLAMAPASAV SGLYFSNLKSKYFAVGKISK DQVEDYALRKNISVAEVEKW LGPILGYDTD |
| Tissue Specificity | Widely expressed. Expressed at the highest levels in pancreas, heart, brain, skeletal muscle and placenta. Expressed at lower levels in lung, liver and kidney. |
| Function | Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine. |
| Protein Name | Methionine SynthaseMs5-Methyltetrahydrofolate--Homocysteine MethyltransferaseCobalamin-Dependent Methionine SynthaseVitamin-B12 Dependent Methionine Synthase |
| Database Links | Reactome: R-HSA-156581Reactome: R-HSA-1614635Reactome: R-HSA-3359467Reactome: R-HSA-3359469Reactome: R-HSA-9013407Reactome: R-HSA-9759218 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Methionine Synthase antibodyAnti-Ms antibodyAnti-5-Methyltetrahydrofolate--Homocysteine Methyltransferase antibodyAnti-Cobalamin-Dependent Methionine Synthase antibodyAnti-Vitamin-B12 Dependent Methionine Synthase antibodyAnti-MTR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
