• Immunohistochemistry analysis of paraffin-embedded rat kidney using MTDH Rabbit monoclonal antibody (STJ11105252) at dilution of 1:300 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of paraffin-embedded mouse kidney using MTDH Rabbit monoclonal antibody (STJ11105252) at dilution of 1:300 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of paraffin-embedded human liver using MTDH Rabbit monoclonal antibody (STJ11105252) at dilution of 1:300 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.

Anti-MTDH antibody (308-407) [S5252RM] (STJ11105252)

SKU:
STJ11105252

€161.88 - €799.38
Current Stock:
Host: Rabbit
Applications: IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-Protein Lyric (308-407) is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: S5252RM
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MTDH
Gene ID: 92140
Uniprot ID: LYRIC_HUMAN
Immunogen Region: 308-407
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 308-407 of human LYRIC/AEG1 (NP_848927.2).
Immunogen Sequence: SPASAGKRKTEPSAWSQDTG DANTNGKDWGRSWSDRSIFS GIGSTAEPVSQSTTSDYQWD VSRNQPYIDDEWSGLNGLSS ADPNSDWNAPAEEWGNWVDE
Tissue Specificity Widely expressed with highest levels in muscle-dominating organs such as skeletal muscle, heart, tongue and small intestine and in endocrine glands such as thyroid and adrenal gland. Overexpressed in various cancers including breast, brain, prostate, melanoma and glioblastoma multiforme.
Function Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.
Protein Name Protein Lyric
3d3/Lyric
Astrocyte Elevated Gene-1 Protein
Aeg-1
Lysine-Rich Ceacam1 Co-Isolated Protein
Metadherin
Metastasis Adhesion Protein
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Membrane Protein
Nucleus Membrane
Cell Junction
Tight Junction
Nucleus
Nucleolus
Cytoplasm
Perinuclear Region
In Epithelial Cells
Recruited To Tight Junctions (Tj) During The Maturation Of The Tj Complexes
A Nucleolar Staining May Be Due To Nuclear Targeting Of An Isoform Lacking The Transmembrane Domain
Tnf-Alpha Causes Translocation From The Cytoplasm To The Nucleus
Alternative Antibody Names Anti-Protein Lyric antibody
Anti-3d3/Lyric antibody
Anti-Astrocyte Elevated Gene-1 Protein antibody
Anti-Aeg-1 antibody
Anti-Lysine-Rich Ceacam1 Co-Isolated Protein antibody
Anti-Metadherin antibody
Anti-Metastasis Adhesion Protein antibody
Anti-MTDH antibody
Anti-AEG1 antibody
Anti-LYRIC antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance