Host: |
Rabbit |
Applications: |
WB/IHC |
Reactivity: |
Human/Mouse/Rat |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-MTA3 (40-330) is suitable for use in Western Blot and Immunohistochemistry research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
Purification: |
Affinity purification |
Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
MTA3 |
Gene ID: |
57504 |
Uniprot ID: |
MTA3_HUMAN |
Immunogen Region: |
40-330 |
Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 40-330 of human MTA3 (NP_065795.1). |
Immunogen Sequence: |
AKVVCFYRRRDISNTLIMLA DKHAKEIEEESETTVEADLT DKQKHQLKHRELFLSRQYES LPATHIRGKCSVALLNETES VLSYLDKEDTFFYSLVYDPS LKTLLADKGEIRVGPRYQAD IPEMLLEGESDEREQSKLEV KVWDPNSPLTDRQIDQFLVV ARAVGTFARALDCSSSVRQP SLHMSAAAASRDITLFHAMD TLYRHSYDLSSAISVLVPLG GPVLCRDEMEEWSASEASL |
Tissue Specificity | Expressed in germinal centers of lymphoid tissues. No expression in nonepithelial cells. |
Function | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6. |
Protein Name | Metastasis-Associated Protein Mta3 |
Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-427389Reactome: R-HSA-73762Reactome: R-HSA-8943724Reactome: R-HSA-9679191 |
Cellular Localisation | NucleusCytoplasm |
Alternative Antibody Names | Anti-Metastasis-Associated Protein Mta3 antibodyAnti-MTA3 antibodyAnti-KIAA1266 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance