| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MS4A2 (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MS4A2 |
| Gene ID: |
2206 |
| Uniprot ID: |
FCERB_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MS4A2 (NP_000130.1). |
| Immunogen Sequence: |
MDTESNRRANLALPQEPSSV PAFEVLEISPQEVSSGRLLK SASSPPLHTWLTVLKKEQEF LGVTQILTAMICLCFGTVVC SVLDISHIEGDIFSSFKAGY |
| Tissue Specificity | Found on the surface of mast cells and basophils. |
| Post Translational Modifications | Phosphorylated on tyrosine residues by LYN. |
| Function | High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy. |
| Protein Name | High Affinity Immunoglobulin Epsilon Receptor Subunit BetaFceriFc Epsilon Receptor I Beta-ChainIge Fc Receptor Subunit BetaMembrane-Spanning 4-Domains Subfamily A Member 2 |
| Database Links | Reactome: R-HSA-2454202Reactome: R-HSA-2730905Reactome: R-HSA-2871796Reactome: R-HSA-2871809Reactome: R-HSA-2871837 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-High Affinity Immunoglobulin Epsilon Receptor Subunit Beta antibodyAnti-Fceri antibodyAnti-Fc Epsilon Receptor I Beta-Chain antibodyAnti-Ige Fc Receptor Subunit Beta antibodyAnti-Membrane-Spanning 4-Domains Subfamily A Member 2 antibodyAnti-MS4A2 antibodyAnti-APY antibodyAnti-FCER1B antibodyAnti-IGER antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
