| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MPRIP (1-310) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MPRIP |
| Gene ID: |
23164 |
| Uniprot ID: |
MPRIP_HUMAN |
| Immunogen Region: |
1-310 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human MPRIP (NP_055949.2). |
| Immunogen Sequence: |
MSAAKENPCRKFQANIFNKS KCQNCFKPRESHLLNDEDLT QAKPIYGGWLLLAPDGTDFD NPVHRSRKWQRRFFILYEHG LLRYALDEMPTTLPQGTINM NQCTDVVDGEGRTGQKFSLC ILTPEKEHFIRAETKEIVSG WLEMLMVYPRTNKQNQKKKR KVEPPTPQEPGPAKVAVTSS SSSSSSSSSIPSAEKVPTTK STLWQEEMRTKDQPDGSSLS PAQSPSQSQPPAASSLREP |
| Function | Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells. |
| Protein Name | Myosin Phosphatase Rho-Interacting ProteinM-RipRho-Interacting Protein 3Rip3P116rip |
| Database Links | Reactome: R-HSA-6802952 |
| Cellular Localisation | CytoplasmCytoskeletonColocalizes With F-Actin |
| Alternative Antibody Names | Anti-Myosin Phosphatase Rho-Interacting Protein antibodyAnti-M-Rip antibodyAnti-Rho-Interacting Protein 3 antibodyAnti-Rip3 antibodyAnti-P116rip antibodyAnti-MPRIP antibodyAnti-KIAA0864 antibodyAnti-MRIP antibodyAnti-RHOIP3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
