| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MPHOSPH10 |
| Gene ID: |
10199 |
| Uniprot ID: |
MPP10_HUMAN |
| Immunogen Region: |
432-681 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 432-681 of human MPHOSPH10 (NP_005782.1). |
| Immunogen Sequence: |
RIRDQAWDDVVRKEKPKEDA YEYKKRLTLDHEKSKLSLAE IYEQEYIKLNQQKTAEEENP EHVEIQKMMDSLFLKLDALS NFHFIPKPPVPEIKVVSNLP AITMEEVAPVSVSDAALLAP EEIKEKNKAGDIKTAAEKTA TDKKRERRKKKYQKRMKIKE KEKRRKLLEKSSVDQAGKYS KTVASEKLKQLTKTGKASFI KDEGKDKALKSSQAFFSKLQ DQVKMQINDAKKTEKKKKK |
| Post Translational Modifications | Phosphorylated in M (mitotic) phase. |
| Function | Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. |
| Protein Name | U3 Small Nucleolar Ribonucleoprotein Protein Mpp10M Phase Phosphoprotein 10 |
| Database Links | Reactome: R-HSA-6790901Reactome: R-HSA-6791226 |
| Cellular Localisation | NucleusNucleolusChromosomeFibrillar Region Of The NucleolusAfter Dissolution Of The Nucleolus In Early M Phase Becomes Associated With Chromosomes Through Metaphase And AnaphaseIn Telophase Localized To Small Cellular Prenucleolar Bodies That Not Always Contain FibrillarinThe Reassociation With Nucleolus Is Preceeded By The Arrival Of Fibrillarin |
| Alternative Antibody Names | Anti-U3 Small Nucleolar Ribonucleoprotein Protein Mpp10 antibodyAnti-M Phase Phosphoprotein 10 antibodyAnti-MPHOSPH10 antibodyAnti-MPP10 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
