| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MOV10 (1-310) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MOV10 |
| Gene ID: |
4343 |
| Uniprot ID: |
MOV10_HUMAN |
| Immunogen Region: |
1-310 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human MOV10 (NP_066014.1). |
| Immunogen Sequence: |
MPSKFSCRQLREAGQCFESF LVVRGLDMETDRERLRTIYN RDFKISFGTPAPGFSSMLYG MKIANLAYVTKTRVRFFRLD RWADVRFPEKRRMKLGSDIS KHHKSLLAKIFYDRAEYLHG KHGVDVEVQGPHEARDGQLL IRLDLNRKEVLTLRLRNGGT QSVTLTHLFPLCRTPQFAFY NEDQELPCPLGPGECYELHV HCKTSFVGYFPATVLWELLG PGESGSEGAGTFYIARFLA |
| Post Translational Modifications | Ubiquitinated by the DCX(DCAF12) complex that specifically recognizes the glutamate-leucine (Glu-Leu) degron at the C-terminus, leading to its degradation. (Microbial infection) Cleaved and targeted for degradation by picornavirus proteases. |
| Function | 5' to 3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission. Plays an important role in innate antiviral immunity by promoting type I interferon production. Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation. Blocks HIV-1 virus replication at a post-entry step. Counteracts HIV-1 Vif-mediated degradation of APOBEC3G through its helicase activity by interfering with the ubiquitin-proteasome pathway. Inhibits also hepatitis B virus/HBV replication by interacting with HBV RNA and thereby inhibiting the early step of viral reverse transcription. Contributes to UPF1 mRNA target degradation by translocation along 3' UTRs. Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2. Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1. Facilitates LINE-1 uridylation by TUT4 and TUT7. Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol. May function as a messenger ribonucleoprotein (mRNP) clearance factor. (Microbial infection) Required for RNA-directed transcription and replication of the human hepatitis delta virus (HDV). Interacts with small capped HDV RNAs derived from genomic hairpin structures that mark the initiation sites of RNA-dependent HDV RNA transcription. |
| Protein Name | Helicase Mov-10Armitage HomologMoloney Leukemia Virus 10 Protein |
| Database Links | Reactome: R-HSA-1912408Reactome: R-HSA-2559580Reactome: R-HSA-2559585Reactome: R-HSA-4086398Reactome: R-HSA-5628897Reactome: R-HSA-5687128Reactome: R-HSA-8853884Reactome: R-HSA-8934593Reactome: R-HSA-8936459Reactome: R-HSA-8943723Reactome: R-HSA-8948700Reactome: R-HSA-8986944Reactome: R-HSA-9018519Reactome: R-HSA-9022692Reactome: R-HSA-9029569Reactome: R-HSA-9759811Reactome: R-HSA-9768778 |
| Cellular Localisation | CytoplasmP-BodyCytoplasmic Ribonucleoprotein GranuleStress GranuleNucleusCo-Enriched In Cytoplasmic Foci With Tut4In Developing NeuronsLocalizes Both In Nucleus And CytoplasmBut In The Adulthood It Is Only CytoplasmicAfter InfectionRelocalizes To The Denv Replication Complex In Perinuclear Regions |
| Alternative Antibody Names | Anti-Helicase Mov-10 antibodyAnti-Armitage Homolog antibodyAnti-Moloney Leukemia Virus 10 Protein antibodyAnti-MOV10 antibodyAnti-KIAA1631 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
