| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AFDN |
| Gene ID: | 4301 |
| Uniprot ID: | AFAD_HUMAN |
| Immunogen Region: | 1510-1680 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1510-1680 of human MLLT4 (NP_001353249.1). |
| Immunogen Sequence: | SLSPDPWKRDAKEKLEKQQQ MHIVDMLSKEIQELQSKPDR SAEESDRLRKLMLEWQFQKR LQESKQKDEDDEEEEDDDVD TMLIMQRLEAERRARLQDEE RRRQQQLEEMRKREAEDRAR QEEERRRQEEERTKRDAEEK RRQEEGYYSRLEAERRRQHD EAARRLLEPEA |
| Function | Belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton. May play a key role in the organization of epithelial structures of the embryonic ectoderm. Essential for the organization of adherens junctions. |
| Protein Name | AfadinAll1-Fused Gene From Chromosome 6 ProteinProtein Af-6Afadin Adherens Junction Formation Factor |
| Database Links | Reactome: R-HSA-418990 P55196-2 |
| Cellular Localisation | Cell JunctionAdherens JunctionNot Found At Cell-Matrix Ajs |
| Alternative Antibody Names | Anti-Afadin antibodyAnti-All1-Fused Gene From Chromosome 6 Protein antibodyAnti-Protein Af-6 antibodyAnti-Afadin Adherens Junction Formation Factor antibodyAnti-AFDN antibodyAnti-AF6 antibodyAnti-MLLT4 antibody |
Information sourced from Uniprot.org