| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MKRN2 (1-240) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MKRN2 |
| Gene ID: |
23609 |
| Uniprot ID: |
MKRN2_HUMAN |
| Immunogen Region: |
1-240 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human MKRN2 (NP_054879.3). |
| Immunogen Sequence: |
MSTKQITCRYFMHGVCREGS QCLFSHDLANSKPSTICKYY QKGYCAYGTRCRYDHTRPSA AAGGAVGTMAHSVPSPAFHS PHPPSEVTASIVKTNSHEPG KREKRTLVLRDRNLSGMAER KTQPSMVSNPGSCSDPQPSP EMKPHSYLDAIRSGLDDVEA SSSYSNEQQLCPYAAAGECR FGDACVYLHGEVCEICRLQV LHPFDPEQRKAHEKICMLTF EHEMEKAFAFQASQDKVCS |
| Tissue Specificity | Expressed in sperm, with significantly reduced expression in sperm of patients with oligoasthenoteratozoospermia (at protein level). Widely expressed with expression in testis, ovary, small intestine, colon, peripheral blood leukocytes, fetal liver, bone marrow, thymus, lymph node and spleen. |
| Function | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Promotes the polyubiquitination and proteasome-dependent degradation of RELA/p65, thereby suppressing RELA-mediated NF-kappaB transactivation and negatively regulating inflammatory responses. Plays a role in the regulation of spermiation and in male fertility. |
| Protein Name | E3 Ubiquitin-Protein Ligase Makorin-2Ring Finger Protein 62Ring-Type E3 Ubiquitin Transferase Makorin-2 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Makorin-2 antibodyAnti-Ring Finger Protein 62 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Makorin-2 antibodyAnti-MKRN2 antibodyAnti-RNF62 antibodyAnti-HSPC070 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
