| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MID2 (476-705) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MID2 |
| Gene ID: |
11043 |
| Uniprot ID: |
TRIM1_HUMAN |
| Immunogen Region: |
476-705 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 476-705 of human MID2 (NP_438112.2). |
| Immunogen Sequence: |
GTRYIFIVKAINQAGSRNSE PTRLKTNSQPFKLDPKMTHK KLKISNDGLQMEKDESSLKK SHTPERFSGTGCYGAAGNIF IDSGCHYWEVVMGSSTWYAI GIAYKSAPKNEWIGKNASSW VFSRCNSNFVVRHNNKEMLV DVPPHLKRLGVLLDYDNNML SFYDPANSLHLHTFDVTFIL PVCPTFTIWNKSLMILSGLP APDFIDYPERQECNCRPQES PYVSGMKTCH |
| Tissue Specificity | Low level in fetal kidney and lung, and in adult prostate, ovary and small intestine. |
| Post Translational Modifications | Phosphorylated on serine and threonine residues. |
| Function | E3 ubiquitin ligase that plays a role in microtubule stabilization. Mediates the 'Lys-48'-linked polyubiquitination of LRRK2 to drive its localization to microtubules and its proteasomal degradation in neurons. This ubiquitination inhibits LRRK2 kinase activation by RAB29. |
| Protein Name | Probable E3 Ubiquitin-Protein Ligase Mid2Midin-2Midline Defect 2Midline-2Ring Finger Protein 60Ring-Type E3 Ubiquitin Transferase Mid2Tripartite Motif-Containing Protein 1 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule-Associated |
| Alternative Antibody Names | Anti-Probable E3 Ubiquitin-Protein Ligase Mid2 antibodyAnti-Midin-2 antibodyAnti-Midline Defect 2 antibodyAnti-Midline-2 antibodyAnti-Ring Finger Protein 60 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Mid2 antibodyAnti-Tripartite Motif-Containing Protein 1 antibodyAnti-MID2 antibodyAnti-FXY2 antibodyAnti-RNF60 antibodyAnti-TRIM1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
